What's this? A classic Spider-Man foe? Here?
Familiarity, as they say, breeds contempt, kids. And the Lizard is a stunning example of the maxim. He's Spider-Man's very own guilt sink, his responsibility made manifest-beloved mentor and raving monster rolled into one. Too often, however, that's all he is. He's trotted out to give Spidey something to angst over for an issue or two, then he's back to normal. In the right hands, that's interesting enough, at times. Other times, he's a joke that has a downer of a punchline (after all, poor Dr. Connors will never be cured of being the Lizard, will he?).
So let's spice it up, shall we?
The Lizard is, in essence, a walking, talking biological weapon. He's everything we fear about genetic testing, stem cell research and the various scientific boogie-men wrapped into one scaly package. So why not play off of that?
When the Hulk bleeds, he bleeds radiation in liquid form. His blood is highly toxic, but also potentially mutagenic. The same for Spider-Man. In fact, most every character in the MU who has been genetically altered in some way is depicted as being something of a living pathogen in regards to spreading their abilities (or a painful death) around via blood, saliva, etc. So why not the Lizard?
Connors Syndrome. Says it all, doesn't it? Spontaneous Reptilian Dimorphism.
Think about it. What if Connors created what would eventually become a virus? Something that attaches itself to other genetic sequences and changes them? Or, better yet, what if it affects everything? Like mold or a fungus? Even inorganic matter can fall victim to Connors Syndrome (Why? Comic book science.). It makes the zombie-plague look like a garden party.
A few of the Lizard's scales left behind at the scene of a fight on the roof of an apartment building take root and spread like mushrooms or weeds, covering the building in a leathery skin, turning it into something out of HR Giger's wet dreams and slowly working a Lovecraftian change on the inhabitants. From there, it gets into the water mains, spreading, slithering through the dark, changing everything it touches into...what?
Definitely something unpleasant.
But then, certain terrorist groups weaponize it, and use it as a biological agent. People buy it, cultivate it, sell it as trendy fashion accessories or as the perfect pet. Others attempt to use it for it's original purpose, i.e. medical. It's penicillin on amphetamines.
Now here's the kicker. As 'patient zero', the Lizard's human alter-ego, Connors, is immune to all of this. In fact, he's the best chance the world has to create an antidote or to figure out a way of controlling the unpleasant side effects. SHIELD is after him, AIM and HYDRA are after him. Silver Sable and the goddamn Wild Pack are after him. Super villains, super heroes, everyone is after him. So Connors is running. Running because he can't trust anyone not to turn his deadly secret into a weapon. And the Lizard...well, the Lizard knows that wherever he goes, the world becomes something beautiful...